Serotonin Noradrenaline Reuptake Inhibitors (SNRIs)
نویسندگان
چکیده
Antidepressants that block the reuptake of serotonin (5-HT) and noradrenaline (NA) are called 5-HT and NA reuptake inhibitors (SNRIs). SNRIs are agents that show “dual action” on 5-HT and NA. These drugs bind the 5-HT transporters (SERT) and NA transporters (NAT) similar to tricyclic antidepressants (TCAs). However, SNRIs differ from TCAs in that SNRIs do not exert much affinity for other receptors. Altough SNRIs are called “dual action” 5-HT NA agents they increase dopamine levels in the prefrontal cortex via NAT inhibition. In this way, they have a third action on neurotransmitters in the prefrontal cortex.
منابع مشابه
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